Nov 10, 2015 · BMP induces differentiation of glioblastoma stem cells GSCs, but it remains unclear if differentiation commitment and permanent cell-cycle arrest occurs. Pollard, Beck, and colleagues report that differentiated progeny of GSCs fail to reconfigure DNA methylation patterns and are vulnerable to de-differentiation. Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells known as glioma stem cells GSCs. This hypothesis states that only a few GSCs are able to divide, differentiate, and initiate a new tumor.
Glioblastoma GBM is the most common primary malignancy of the brain, as well as its most malignant, and is classified as Grade IV on the World Health Organization WHO scale . Despite years of advances in therapy, the median survival after radiation and chemotherapy ranges from 12. Increasing evidence exposes a subpopulation of cancer cells, known as cancer stem cells CSCs, to be critical for the progression of several human malignancies, including glioblastoma multiforme. CSCs are highly tumorigenic, capable of self-renewal, and resistant to conventional therapies, and thus considered to be one of the key contributors. Differentiation of glioblastoma multiforme stem-like cells leads to downregulation of EGFR and EGFRvIII and decreased tumorigenic and stem-like cell potential. Mar 07, 2014 · Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a. Nov 21, 2010 · Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.The recent demonstration that a population of glioblastoma stem-like cells GSCs maintains glioblastomas 1,2 indicates that the progeny of these cells may not be confined to the neural lineage 3. Normal neural stem cells are able to differentiate.
highly tumorigenic subpopulation of glioblastoma stem-like cells GSLCs present in the tumor and defined as a subpopulation of cells with stem-like properties, such as self-renewal, asymmetric division, and differentiation potential, essential for tumor development and propaga-tion in vivo 8,45 are presumably causative for GBM recurrence. Jun 01, 2012 · Olig1 and Olig2 are expressed by oligodendrogliomas and by subsets of cells, including CD133stem-like cells found in malignant astrocytomas. Through these interactions, Id proteins play crucial roles in regulating cell proliferation, survival, lineage-dependent differentiation, and cell–cell. Nov 21, 2010 · Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic. Distinct epigenetic state enables glioblastoma GBM cells to propagate tumors in vivo Four TFs reprogram differentiated GBM cells into tumor-propagating stem-like cells These four TFs are coordinately expressed in stem-like cells in primary human tumors The TF target LSD1 may serve as a therapeutic target in tumor-propagating cells. Jul 03, 2014 · Glioblastoma multiforme is the most common malignant brain tumor in adults, with an average survival of less than one year due to its resistance to therapy. -differentiated glioblastoma cells.
enhancing the conversion of non-stem glioblastoma multiforme cells to highly inﬁltrative, tumor-initiating stem-like cells 16–18. These data argue against the unidirectional ﬂow of cellular hierarchy, increasing the possibility that the fate of these cancer cells. Glioblastomas show heterogeneous histological features. These distinct phenotypic states are thought to be associated with the presence of glioma stem cells GSCs, which are highly tumorigenic and self-renewing sub-population of tumor cells that have different functional characteristics.
Involvement of miRNAs in the Differentiation of Human Glioblastoma Multiforme Stem-Like Cells Article PDF Available in PLoS ONE 810:e77098 · October. cells  also called cancer stem-like cells, here termed glioblastoma stem cells GSCs. Similar cells have been found in many, although not in all human tumors. These "roots of cancer" operate in a hierarchical fashion such as conceptualized for normal stem cells . The authors of this work reviewed the evolution of the cancer stem cell. Involvement of miRNAs in the Differentiation of Human Glioblastoma Multiforme Stem-Like Cells Beatriz Aldaz1,5, Ainara Sagardoy1, Lorena Nogueira2, Elizabeth Guruceaga3, Lara Grande2, Jason T. Glioblastoma GBM is a neoplasm characterized by an extensive blood vessel network. Hypoxic niches of GBM can induce tumorigenic properties of a small cell subpopulation called Glioblastoma stem-like cells GSCs and can also increase extracellular adenosine generation which activates the A3 adenosine receptor A3AR. Moreover, GSCs potentiates the persistent neovascularization in GBM.
Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors Article in Glia 612 · February 2013 with 327 Reads How we measure 'reads'. significance of cancer stem cell markers in Glioblastoma multiforme. Cancer stem cells Recently, cancer stem cells become a major focus area in cancer research. Clarke et al. 33 reported about CSCs, a cancer cell have the ability of self renewal and differentiation into multiple cell lineages that play the major role in the heterogeneity. Oct 01, 2015 · Differentiation has been proposed as a therapeutic strategy for glioblastoma GBM in part due to observations of stem-like cells in GBM that have been shown to undergo terminal differentiation in response to growth factor withdrawal and BMP activation. Mar 05, 2013 · Brain tumor neurospheres BTCSs are cancer cells with neural stem cell-like properties found in the fatal brain tumor glioblastoma multiforme GBM. These cells account for less than 1% of total tumor cells, are poorly differentiated and are believed to be involved in tumor induction, progression, treatment resistance and relapse. Specific miRNAs play important roles in modulating the.
Human brain tumors appear to have a hierarchical cellular organization suggestive of a stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines would provide a powerful model system to study their biology. Here, we demonstrate routine and efficient derivation of adherent cell lines from malignant glioma that display stem cell properties and initiate high. Mar 02, 2007 · Here, we show that glioma stem-like cells derived from glioblastoma multiforme biopsies and the glioma cell lines U87MG and U373MG express cannabinoid type 1 CB 1 and type 2 CB 2 receptors and other elements of the endocannabinoid system. In gene array experiments, CB receptor activation altered the expression of genes involved in the.
Oct 15, 2015 · Glioma stem-like cells GSCs correspond to a tumor cell subpopulation, involved in glioblastoma multiforme GBM tumor initiation and acquired chemoresistance. Currently, drug-induced differentiation is considered as a promising approach to eradicate this tumor-driving cell population.
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